Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions
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Complex formation between polyacrylic acid and cationic/nonionic mixed micelles: effect of pH on electrostatic interaction and hydrogen bonding
The interaction of a weak polyacid, sodium polyacrylate (PAA), and cationic mixed micelles of n-hexadecyl trimethyl ammonium chloride/n-dodecyl hexaoxyethylene glycol monoether (CTAC/C12E8) was studied by turbidimetric titrations at varying pH, in order to determine the effect of polymer charge. Electrostatically-driven complex formation is controlled by three variables: the polymer linear char...
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The kinetics of dissolution of dispersions of egg phosphatidylcholine (lecithin) by bile salts was studied by observing the decrease in turbidity as mixed micelles of lecithin and bile salt were formed. The rate of dissolution of lecithin corresponding to the formation of mixed micelles was studied in the presence of dihydroxy bile salts, sodium deoxycholate, sodium chenodeoxycholate, sodium ur...
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Background/Aims: The bile salt-activated farnesoid X receptor (FXR; NR1H4) controls expression of several genes considered crucial in maintenance of bile salt homeostasis. We evaluated the physiological consequences of FXR defi ciency on bile formation and on the kinetics of the enterohepatic circulation of cholate, the major bile salt species in mice. Methods: The pool size, fractional turnove...
متن کاملFetal bile salt metabolism. The intestinal absorption of bile salt.
The intestinal absorption of sodium taurocholate was studied in the near-term fetal and neonatal dog. Absorption rates were measured in vivo in isolated loops of fetal jejunum and ileum. Absorption was also measured in vitro in everted sacs and rings of fetal and neonatal jejunum and ileum. The maximal rates of taurocholate absorption observed after instillation of 1 micronmol taurocholate into...
متن کاملMixed micelles of cationic surfactants and sodium cholate in water.
Critical micelle concentrations (CMCs) of cationic surfactant (alkyltrimethylammonium bromides, CnTABr, where n = 10, 12, 14, 16 and 18), and a bile salt sodium cholate (NaC) were determined from surface tension, conductance and dye solubilization methods, while of their equimolar mixtures from surface tension and dye solubilization methods. The interaction parameter (beta) obtained from analys...
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ژورنال
عنوان ژورنال: Molecules
سال: 2020
ISSN: 1420-3049
DOI: 10.3390/molecules25030546